The Enterohepatic Circulation
نویسندگان
چکیده
منابع مشابه
Enterohepatic circulation of sulphur in female goats.
Sulphur flow through the gut was monitored in eight adult female goats at different stages in their reproductive cycle. The amount of S transferred from the body into digesta between the mouth and the transverse duodenum was directly proportional to the amount of nitrogen retained in the body and secreted in milk. S secretion into digesta was also a function of metabolic body-weight (body-weigh...
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Background/Aims: The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several genes considered crucial in maintenance of bile salt homeostasis. We evaluated the physiological consequences of FXR defi ciency on bile formation and on the kinetics of the enterohepatic circulation of cholate, the major bile salt species in mice. Methods: The pool size, fractional turnove...
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This article summarizes the impact of the pharmacogenetics of drug transporters expressed in the enterohepatic circulation on the pharmacokinetics and pharmacodynamics of drugs. The role of pharmacogenetics in the function of drug transporter proteins in vitro is now well established and evidence is rapidly accumulating from in vivo pharmacokinetic studies, which suggests that genetic variants ...
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The present study describes a novel technique for investigations of the enterohepatic circulation in the hamster with an extracorporeal bile duct that allows long-term bile collection in the free-moving animal. The animals recovered for 7 days after the operation before the external loop was cut and bile was collected over a period of 78 h. Under these optimal conditions, initial bile flow (651...
متن کاملDrug enterohepatic circulation and disposition: constituents of systems pharmacokinetics.
Drug disposition information constitutes a part of systems pharmacokinetics, and becomes imperative when a drug shows significant effects at its disproportionally low blood concentration. The situation could result from outweighing the parent drug in tissues over in blood and/or from its active metabolites. Fractions of certain drugs absorbed from the intestine to the systemic circulation via t...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1972
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(72)80018-0